About Microbiota
Microbiota, a diverse community of microorganisms, plays a crucial role in health and disease development, significantly impacting individualized drug responses. Understanding the intricate relationships between microbiota, drugs, and diseases, especially through microbiota-related proteins, is essential for advancing precision medicine and improving drug efficacy.
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The Information Provided in the MDIPID
The Complex Interrelationships Among Microbiota (& Their Proteins), Drugs, and Diseases can be Categorized into the Following Three Main Types:
α. Microbiota & Their Related Proteins (MRPS) Modulation on Drug Response (MMDR)
6,669 MMDR data of 628 microbial species modulation on 881 drugs were described, involving 592 microbial proteins from 282 microbial species and 15 types of drug modulation, such as activation, metabolic modification, and sequestration.
6,669 MMDR data of 628 microbial species modulation on 881 drugs were described, involving 592 microbial proteins from 282 microbial species and 15 types of drug modulation, such as activation, metabolic modification, and sequestration.
β. Drug or Other Exogenous Substances Impact on Microbiota (DEIM)
11,760 DEIM data of 921 microbiota variation induced by 1,066 drugs/substances were provided, covering 10 classes of impact on microbiota, such as increasing/decreasing the relative abundance, reducing the growth.
11,760 DEIM data of 921 microbiota variation induced by 1,066 drugs/substances were provided, covering 10 classes of impact on microbiota, such as increasing/decreasing the relative abundance, reducing the growth.
γ. Microbiota-Disease Associations (MBDA)
15,146 MBDA data between 2,209 microbial species and 482 diseases were offered, regarding 10 types of microbiota variation, such as decrease, increase, and enrich
15,146 MBDA data between 2,209 microbial species and 482 diseases were offered, regarding 10 types of microbiota variation, such as decrease, increase, and enrich
Moreover, the three categories of data that were collected in MDIPID, collectively comprise a comprehensive and interconnected network, covering 1,818 drugs/substances, 2,708 microbial species, 482 diseases, and 592 microbiota-related proteins.